Here is a neat trick that unfortunately looks to be Windows only. Skype can be made to run on a non-U3 thumb drive and it can be accomplished by mere mortals without any special skills. All you need to do is copy the right files from your PC into the right directories on your thumb drive and then modify the skype.bat file in notepad.

Really, it is as simple as that. Head over to MakeUseOf.com for full instructions on what to do. [MakeUseOf via Life Hacker]

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